Progress in Immunotherapy for Alzheimer’s disease-How to Overcome Recently Found Obstacles
نویسندگان
چکیده
Twenty years have passed since Schenk et al. developed peptide vaccines for Alzheimer’s disease (AD). However, subsequent clinical trials with active and passive immunization have failed to obtain sufficient outcomes to halt or improve cognitive decline. Other non-immunological therapies have also been unsuccessful in achieving satisfactory results. In this review article, we analyze factors regulating the results of these outcomes and look for ways in overcoming them. We also introduce recently developed DNA vaccines that targets both Aβ and tau deposits.
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